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Publications
Journal articles
Ohshima T.
2010
  • Tsutsumi K, Takano T, Endo R, Fukuda M, Ohshima T,Tomomura M, Hisanaga S. (2010) Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. PLoS ONE 5(4): e10260. doi:10.1371/journal.pone.0010260
2009
  • Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB. (2009) Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. American J. Pathology. 176,320-329.
  • Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y. (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J. Biol. Chem. 284, 27393-401.
  • Endo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga S. (2009) Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 Cyclin-dependent kinase 5 activator. J. Biol. Chem. 284, 26029-39.
  • Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y. (2009) Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice. J. Comp. Neurol. 516, 360-375.
2008
  • Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S. (2008) Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. J. Neurosci. 28, 8747-55.
2007
  • Hirota Y, Ohshima T, Kaneko N, Ikeda M, Iwasato T, Kulkarni AB, Mikoshiba K, Okano H, Sawamoto K. (2007) Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J. Neurosci. 27, 12829-38.
  • Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y. (2007) Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J. Neurosci. 27, 12546-54.
  • Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S. (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat. Neurosci. 10, 1141-50.
  • Ohshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, Saruta K, Iwasato T, Itohara S, Hashimoto M, Nakajima K, Ogawa M, Kulkarni AB, Mikoshiba K. (2007) Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development 134, 2273-2282.
  • Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K. (2007) Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res. 1140, 84-95.
  • Hayashi K, Ohshima T, Hashimoto M, Mikoshiba K. (2007) Pak1 regulates dendritic branching and spine formation. Dev. Neurobiol.　67, 655-669.
2006
  • Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T. Goshima Y. (2006)　CRMP1 mediates Reelin signaling in cortical neuronal migration. J. Neurosci. 26, 13357-62.
  • Hayashi K, Pan Y, Shu H, Ohshima T , Kansy W J, White C L III, Tamminga C A, Sobel A, Curmi P A, Mikoshiba K, Bibb J A. (2006) Phosphorylation of the tubulin binding protein, stathmin by Cdk5 and MAP kinase in the brain. J. Neurochem.　99, 237-250.
2005
  • Li C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T, Nakamura F, Yagi T, Ohshima T, Goshima Y. (2005) Correlation between Semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E. J. Neurosci. 24, 6161-6170.
  • Wei F, Nagashima K, Ohshima T. Saheki Y, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K. (2005) Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat. Med. 11, 1104-1108.
  • Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb J A, Hisanaga S, Matsui H, Mikoshiba K. (2005) Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice. J. Neurochem. 94, 917-25.
  • Wei F, Tomizawa K, Ohshima T, Asada A, Saito T, Nguyen C, Bibb J A, Ishiguro K, Kulkarni A B, Pant H C, Mikoshiba K, Hisanaga S. (2005) Control of Cdk5 activity by glutamatergic regulation of p35 stability. J. Neurochem.　93, 502-512.
  • Takahashi S, Ohshima T, Cho A, Sreenth T, Iadaroa M J, Pant H C, Kim Y, Narin A C, Brady R O, Greegard P, Kulkarni A B. (2005) Increased activity of cyclin-dependent kinase 5 leads to attenuating of cocaine-mediated dopamine signaling. Proc. Natl. Acad. Sci. USA 102, 1737-1742.
  • Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y. (2005) Semaphorin-3A signaling is mediated via sequential Cdk5-GSK3b phosphorylation of CRMP2：implication of common phosphorylating mechanism underlying axon guidance and Alzheimer’s disease. Genes to Cells 10, 165-179.
Tanaka H.
2009
  • Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H, (2009) Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain, Development 136, 1653-1663.
2008
  • Nishiwaki Y, Komori A, Sagara H, Suzuki E, Manabe T, Hosoya T, Nojima Y, Wada H, Tanaka H, Okamoto H, Masai I, (2008) Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish, Mech. Dev. 125, 932-946.
2007
  • Tanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, Kobayashi M, Nakayama R, Okamoto H, (2007) Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons. Development 134, 3259-3269.
2006
  • Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H, (2006) Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development 133, 4749-4759.
2005
  • Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, Sato A, Nojima Y,Okamoto H, (2005) Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos. Development 132, 2273-2285.
  • Kawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, Wada H, Masai I, Terasaki H, Sakaki Y, Takeda H, Okamoto H, (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range　regulation of hedgehog signaling. Curr. Biol. 8, 480-488
Jin J.
2010
  • Jin J, Suzuki H, Hirai S, Mikoshiba K, Ohshima T. (2010) JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration. Dev. Neurobiol. 70, 929-942.
Ito Y.
2010
  • Ito Y, Tanaka H, Okamoto H, Ohshima T. (2010) Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum. Dev. Biol.　342, 26-38.
Amo R.
2010
  • Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, Okamoto H. (2010) Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. J. Neurosci. 30(4), 1566-1574.

Conferences
Ohshima T.
2009
  • Invited lecture: Ohshima T. "Requirement of Cdk5 for proper cerebellar development and function." 2nd international symposium on Cdk5. Tokyo. June 26-27.
Tanaka H.
2010
  • Tanaka H, Yoko Ito, Hitoshi Okamoto, Toshio Ohshima,
    "Cellular response of the adult zebrafish optic tectum following eye removal"
    16th Japanese Medaka and Zebrafish Meeting, September 18-19.
  • Tanaka H, Yoko Ito, Hitoshi Okamoto, Toshio Ohshima,
    "Cellular response of the adult zebrafish optic tectum following eye removal"
    9th International Conference on Zebrafish Development & Genetics
    (2010) Madison, Wisconsin, USA.
  • Tanaka H. "Analysis of adult neurogenesis in zebrafish."The 7th Joint Symposium between the University of Bonn and Waseda University. Bonn, Germany. January
2009
  • Tanaka H."Analysis of neurological disorder using Zebrafish" on how to foster young researchers in biochemical field. Yamanishi University. Oct 3
  • Tanaka H, Ito Y, Okamoto H, Ohshima T. "Expression profiling of neural precursor cell markers in the adult zebrafish optic tectum" 6th Europian Zebrafish Genetics and Development Meeting. Rome, ItalyJuly
  • Tanaka H. "Zebrafish: as a model organism for developmental neurobiolog." The 6th Joint Symposium between the University of Bonn and Waseda University. Tokyo, June 18.
Jin J.
2010
  • Jin J, Suzuki H, Hirai S, Mikoshiba K, Ohshima T. "JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration". Neuro 2010, September 2-4.
Ito Y.
2010
  • Ito Y, Tanaka H, Okamoto H, and Ohshima T. "Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum". 16th Japanese Medaka and Zebrafish Meeting, September 18-19.
  • Ito Y, Tanaka H, Okamoto H, and Ohshima T. "Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum". 9th International Meeting on Zebrafish Development and Genetics, Madison, Wisconsin, US, June 2010.
2009
  • Ito Y, Tanaka H,Okamoto H,Ohshima T. "Characterization of neural stem cells in the adult zebrafish optic tectum.". The 32nd annural meeting held by the molecular biology society of Japan. Yokohama. Dec 10.
  • Ito Y, Tanaka H, Okamoto H, Ohshima T. "Expression profiling of neural precursor cell markers in the adult zebrafish optic tectum." Waseda univ. High-Tech Research Center - The 1st International　Symposium on Biomedical Science and Engineering. Tokyo. July 18.
Niisato E.
2010
  • Niisato E, Yamashita N, Nakamura F, Goshima Y, Ohshima T. "Role of collapsin response mediator proteins for dendritic development in hippocampal CA1 pyramidal neurons". Neuro 2010, September 2-4.
Kono H.
2010
  • Kono H, Tanaka H, Ohshima T. "Effects of valproic acid for development of the nervous system in zebrafish". 16th Japanese Medaka and Zebrafish Meeting, September 18-19.
Morimura R.
2010
  • Morimura R, Tanaka H, Oshima T. "Role of CRMP2,4 proteins and their phosphorylation for determination of neuronal position during neurulation". 16th Japanese Medaka and Zebrafish Meeting, September 18-19.
Chapters
Ohshima T.
2009
  • Ohshima T. Neuron migrtion and Cdk5. Protein　Nucleic acid　Enzyme. 共立出版. 54, 796-801. Japanese.
2008
  • Ohshima T. Cdk5/p35 regulates neuronal migration. in Ip N, Tsai L. (Eds.) Cyclin Dependent Kinase5. Spriger. 1-8.